10 Crucial Warning Signs of Celiac Disease You Shouldn’t Ignore

March 26, 2025

Celiac disease is a complex autoimmune disorder that remains enigmatic to many. Despite affecting approximately 1% of the global population, it is often misunderstood or overlooked due to its diverse and sometimes non-specific symptoms. The disease is triggered by the ingestion of gluten, a protein found in wheat, barley, and rye, leading to inflammation and damage in the small intestine. This damage can result in a myriad of symptoms, ranging from digestive issues to neurological complications. The challenge lies in the fact that these symptoms can mimic other conditions, often leading to delayed diagnosis. The purpose of this article is to illuminate the top 10 warning signs of celiac disease, providing you with the knowledge to recognize and address this stealthy condition. By understanding these signs, you can take proactive steps towards seeking medical advice and managing your health effectively. As we delve into each symptom, remember that celiac disease is a spectrum disorder, and its manifestations can vary significantly from person to person.

1. Digestive Distress: The Most Common Indicator

hand making a bracket with a gut icon in the middle. Photo Credit: Envato @fauziEv8

Digestive problems are the hallmark of celiac disease and often the first clue that something is amiss. Individuals with celiac disease may experience chronic diarrhea, abdominal pain, bloating, and gas. These symptoms occur because the ingestion of gluten triggers an immune response that damages the villi in the small intestine, impairing nutrient absorption. This malabsorption leads to the digestive discomfort that many celiac patients report. However, it is important to note that not everyone with celiac disease will experience these classic gastrointestinal symptoms. Some may have constipation instead of diarrhea, or experience no digestive issues at all. This variability can make it challenging to link these symptoms directly to celiac disease. Nonetheless, persistent digestive distress, especially when accompanied by other symptoms, should prompt further investigation. A healthcare provider can perform specific blood tests and, if necessary, an intestinal biopsy to confirm a diagnosis of celiac disease.

2. Unexplained Weight Loss: A Red Flag

Concept of weight loss with slim girl. Photo Credit: Envato @AtlasComposer

Unexplained weight loss is another significant warning sign of celiac disease. As the small intestine becomes damaged, its ability to absorb nutrients diminishes. This malabsorption can lead to weight loss, even if the individual maintains a normal or increased appetite. In some cases, people may also experience muscle wasting and a general sense of weakness or fatigue. Weight loss in celiac disease is not always extreme but can be noticeable over time. It is important to differentiate this from weight loss due to other factors, such as increased physical activity or dietary changes. If weight loss occurs alongside other symptoms like digestive issues or fatigue, it warrants a closer look. Early detection and treatment of celiac disease can help halt and reverse the malabsorption process, allowing for weight stabilization and improved overall health. Therefore, unexplained weight loss should not be ignored, especially if it persists despite dietary adjustments.

3. Anemia: The Hidden Deficiency

Anemia and iron pills. Photo Credit: Envato @ElinaVeresk

Anemia, particularly iron-deficiency anemia, is a common symptom of celiac disease. The damage to the small intestine affects the absorption of vital nutrients, including iron, which is essential for the production of hemoglobin in red blood cells. As a result, individuals with celiac disease may develop anemia, leading to symptoms such as fatigue, weakness, dizziness, and pale skin. In some cases, they may also experience shortness of breath or an increased heart rate. Anemia can be particularly insidious because it may develop gradually, making it difficult to pinpoint the exact cause. If left untreated, it can lead to more severe complications, such as heart problems or developmental delays in children. Therefore, if you experience symptoms of anemia and have other risk factors or symptoms of celiac disease, it is crucial to seek medical evaluation. A simple blood test can help determine your iron levels and guide further testing for celiac disease.

4. Dermatitis Herpetiformis: The Skin Connection

Dermatitis rash viral disease with immunodeficiency on body of young adult asian. Photo Credit: Envato @Mumemories

Dermatitis herpetiformis (DH) is a skin manifestation of celiac disease, characterized by an intensely itchy and blistering rash. This condition occurs when gluten ingestion triggers an immune response that affects the skin, rather than the gut. The rash typically appears on the elbows, knees, buttocks, and scalp, and can be extremely uncomfortable. While DH is not as common as other symptoms of celiac disease, it is a definitive indicator of the condition. People with DH often have a milder form of intestinal damage, but the presence of the rash alone is enough to diagnose celiac disease. Treatment involves a strict gluten-free diet, which helps alleviate the rash over time, and may also include medications to control itching. Recognizing DH is crucial, as it provides a direct link to celiac disease and can expedite diagnosis and treatment. If you suspect you have DH, consult a dermatologist or healthcare provider for evaluation and management.

5. Fatigue: The Overlooked Symptom

Overworked business lady is having eyes fatigue. Photo Credit: Envato @svitlanah

Fatigue is a prevalent yet often overlooked symptom of celiac disease. It can arise from several factors, including malabsorption of nutrients, anemia, and the body's chronic inflammatory response to gluten. This fatigue is more than just feeling tired; it is a pervasive sense of exhaustion that does not improve with rest. It can affect daily functioning and quality of life, making it difficult to concentrate or perform routine tasks. Many individuals with celiac disease report feeling "foggy" or lacking mental clarity, a condition often referred to as "brain fog." This symptom can be particularly frustrating, as it may not be immediately associated with celiac disease. However, if you experience persistent fatigue along with other symptoms, it is worth exploring the possibility of celiac disease. Adopting a gluten-free diet can significantly improve energy levels and cognitive function, highlighting the importance of recognizing and addressing this symptom.

6. Bone and Joint Pain: The Silent Ache

The problem of pain in the knee joint - arthritis and arthrosis in a female athlete. Photo Credit: Envato @svetlaya_83

Bone and joint pain are lesser-known symptoms of celiac disease but can be indicative of underlying issues. The malabsorption of calcium and vitamin D, essential nutrients for bone health, can lead to weakened bones and conditions such as osteoporosis or osteopenia. This can result in bone pain, fractures, and joint discomfort. Additionally, the chronic inflammation associated with celiac disease can contribute to joint pain and stiffness. These symptoms may be mistaken for other conditions, such as arthritis, delaying proper diagnosis and treatment. It is crucial to consider celiac disease as a potential cause of bone and joint pain, especially if other symptoms are present. Early diagnosis and a gluten-free diet can help improve bone density and reduce pain, preventing long-term complications. If you experience unexplained bone or joint pain, consult a healthcare provider for a thorough evaluation and appropriate testing.

7. Neurological Symptoms: The Mind-Body Connection

Hand holding wooden triangle with text MIND and BODY on balancing scale. Photo Credit: Envato @mohdizzuanbinroslan

Celiac disease can have a profound impact on the nervous system, leading to a range of neurological symptoms. These may include headaches, migraines, peripheral neuropathy (tingling or numbness in the hands and feet), and even balance issues. The exact mechanism behind these symptoms is not fully understood, but it is believed to involve an immune-mediated response to gluten that affects the nervous system. Neurological symptoms can be particularly distressing and may significantly impact quality of life. They can also be challenging to diagnose, as they may mimic other neurological disorders. If you experience persistent neurological symptoms alongside digestive or other signs of celiac disease, it is important to consider this condition as a potential cause. A gluten-free diet can lead to significant improvements in neurological symptoms, highlighting the importance of early recognition and intervention. Consult a neurologist or healthcare provider for a comprehensive evaluation if you suspect a connection between your symptoms and celiac disease.

8. Reproductive Health Issues: An Unexpected Link

Infertility problem. Caucasian couple sitting on bed with negative pregnancy test result. Photo Credit: Envato @Prostock-studio

Celiac disease can affect reproductive health in both men and women, leading to issues such as infertility, recurrent miscarriages, and menstrual irregularities. The malabsorption of essential nutrients and the body's inflammatory response to gluten can disrupt hormonal balance and reproductive function. In women, celiac disease may cause delayed menarche, amenorrhea (absence of menstruation), or early menopause. In men, it can lead to reduced fertility or low testosterone levels. These reproductive health issues can be distressing and may not immediately be linked to celiac disease. However, if you experience unexplained reproductive health problems along with other symptoms, it is worth considering celiac disease as a potential underlying cause. Early diagnosis and treatment with a gluten-free diet can improve reproductive health outcomes and increase the chances of successful conception and pregnancy. If you have concerns about your reproductive health, consult a healthcare provider for a thorough evaluation and appropriate testing.

9. Psychological Symptoms: The Emotional Toll

Sad woman. Photo Credit: Envato @Olezzo

Celiac disease can take a significant emotional toll, leading to psychological symptoms such as depression, anxiety, and mood swings. The chronic nature of the disease, combined with the challenges of adhering to a strict gluten-free diet, can contribute to feelings of isolation and frustration. Additionally, the malabsorption of nutrients essential for brain health, such as B vitamins and omega-3 fatty acids, can exacerbate mood disorders. It is important to recognize that these psychological symptoms are not merely a result of living with a chronic illness but may be directly linked to the disease itself. Addressing these symptoms requires a comprehensive approach that includes dietary management, psychological support, and, if necessary, medication. If you experience persistent psychological symptoms alongside other signs of celiac disease, seek support from a mental health professional and a healthcare provider. Early intervention can improve mental well-being and overall quality of life, emphasizing the importance of recognizing and addressing this aspect of celiac disease.

10. Persistent Mouth Ulcers: An Overlooked Sign

A woman feels a burn in her mouth because of using mouthwash. Photo Credit: Envato @eddows_arunothai

Frequent mouth ulcers, also known as canker sores, can be an unexpected but telling sign of celiac disease. These painful sores can develop on the inside of the cheeks, lips, tongue, or gums and may be recurrent. The exact reason why celiac disease contributes to mouth ulcers isn’t entirely understood, but it's likely linked to nutrient deficiencies, particularly in iron, folate, and B vitamins, which are essential for maintaining healthy mucous membranes. Additionally, ongoing inflammation caused by an immune response to gluten may contribute to the frequent occurrence of these sores. Unlike occasional ulcers that may arise from stress or minor injuries, those associated with celiac disease tend to be persistent and difficult to heal. If you find yourself dealing with recurrent mouth ulcers alongside other symptoms like digestive distress, fatigue, or joint pain, it could be a sign that your body is reacting to gluten. Seeking medical evaluation and considering celiac testing could provide answers. Once diagnosed, following a strict gluten-free diet can often lead to significant improvements, including a reduction in mouth ulcers and other oral health issues.

Empowering Awareness and Action

Gluten free food. Various pasta, bread and snacks on wooden background from top view. Photo Credit: Envato @master1305

Unmasking the top 10 warning signs of celiac disease is crucial for timely diagnosis and effective management. Each symptom, from digestive distress to psychological challenges, provides a piece of the puzzle that can lead to a comprehensive understanding of this complex condition. Recognizing these signs empowers individuals to seek medical advice, undergo appropriate testing, and adopt a gluten-free diet that can significantly improve health outcomes. It is important to remember that celiac disease is a lifelong condition, but with proper management, individuals can lead healthy and fulfilling lives. Raising awareness about the diverse manifestations of celiac disease can reduce the stigma and misconceptions surrounding the condition, fostering a supportive environment for those affected. By staying informed and proactive, you can take control of your health and well-being, ensuring a brighter and healthier future. If you suspect you or a loved one may have celiac disease, do not hesitate to reach out to a healthcare provider for guidance and support.

MORE FROM HealthPrep