Diarrhea or constipation, problems with health concept. Photo Credit: Envato @thichas
Acetaminophen is often chosen over NSAIDs for its lower risk of gastrointestinal irritation, but it is not entirely free from digestive side effects. High doses or prolonged use of acetaminophen can lead to gastric irritation, nausea, or, in rare cases, gastrointestinal bleeding. This risk increases when acetaminophen is combined with alcohol or taken alongside other medications that stress the stomach lining. While less common than with NSAIDs, ulcers and erosions in the gastrointestinal tract can still occur, especially in individuals with pre-existing digestive conditions. Symptoms like persistent abdominal pain, vomiting, or blood in stool should be treated as warning signs of a potential issue. Choosing the lowest effective dose and taking acetaminophen with food can help mitigate these risks. For those with a history of gastrointestinal issues, consulting a healthcare provider about alternative pain relief options may provide a safer course of action.
Urticaria is an allergic reaction on the skin. Red spots on the skin. Photo Credit: Envato @epovdima
Although rare, acetaminophen can trigger severe allergic reactions or life-threatening skin disorders like Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). These conditions are characterized by widespread skin blistering, peeling, and flu-like symptoms, including fever and malaise. In some cases, the reaction begins with a rash or mild irritation, progressing rapidly to more serious complications if left untreated. Such reactions are medical emergencies requiring immediate intervention. While the exact mechanism behind these reactions remains unclear, they are believed to involve an overactive immune response to acetaminophen or its metabolites. Individuals with a history of drug allergies may face a higher risk and should consult their doctor before using acetaminophen. If any unusual skin changes occur while taking the medication, discontinuing use and seeking medical attention promptly is critical. Raising awareness about these rare but serious side effects can help prevent delays in treatment.
