21 Unexpected Twists and Turns in the World of Prednisone

3. What Is Prednisone Used For? More Than You Think

Most people know prednisone as a treatment for arthritis and asthma, but its uses extend far beyond that. It’s commonly prescribed for autoimmune diseases like lupus, Crohn’s disease, and ulcerative colitis, where it works to calm an overactive immune system. It also plays a critical role in cancer treatment, often used in combination with chemotherapy to reduce inflammation and manage symptoms. Additionally, prednisone is a lifesaver for organ transplant recipients, preventing the body from rejecting a new organ. Surprisingly, it’s also used for adrenal insufficiency, replacing the cortisol that the body fails to produce on its own.

4. Common Side Effects: The Good, The Bad, and The Unexpected

Prednisone can be a double-edged sword—relieving symptoms while causing unwanted changes in the body. Patients often report increased appetite, weight gain, and mood swings, alongside insomnia, headaches, and stomach discomfort. Skin thinning, easy bruising, and acne are also common, as the drug alters collagen production. One of prednisone’s stranger effects is fat redistribution, where fat accumulates in the face, neck, waist, and upper back, giving some patients the telltale "moon face" look. While many side effects fade once the medication is stopped, some—like bone loss or high blood sugar—can linger.