While Omeprazole is widely recognized for its ability to alleviate heartburn, its clinical applications extend far beyond this common ailment. There is a diverse range of conditions that benefit from Omeprazole therapy. GERD, characterized by chronic acid reflux, is perhaps the most well-known condition treated with Omeprazole. However, its use in managing peptic ulcers, including those caused by Helicobacter pylori infection, is equally significant. Omeprazole is also employed in the treatment of Zollinger-Ellison syndrome, a rare condition marked by excessive acid production. Furthermore, its role in preventing gastric damage in patients requiring long-term NSAID therapy highlights its protective capabilities. By examining these clinical applications, this section underscores Omeprazole's versatility and its importance in both acute and chronic treatment regimens.