A more serious, but unseen, symptom of acquired hemolytic anemia is the development of a heart murmur. This condition is generally described as an unusual sound, ranging from faint to loud, between regular heartbeats. Medical professionals have reported these murmurs as a swishing or whooshing sound. Depending on the loudness of the murmur, it may be challenging to detect. For those suffering from acquired hemolytic anemia, heart murmurs occur because of the absence of red blood cells. Because red blood cells carry much-needed oxygen to the organs and tissue of the body, a lack of these blood cells forces the heart to work harder to move oxygenated blood to throughout the body, and thus, causes the murmur.