Breakdown Of Platelets
Several factors are known to cause the breakdown of platelets, and as mentioned, the immune system plays a role in the platelet reduction. The body destroying more platelets than necessary can cause a low platelet count. When platelets are formed, they circulate for up to ten days before being removed from the bloodstream so the body can make new ones. In some cases, low platelet count occurs as the result of an enlarged spleen, which actually occurs due to an excessive amount of platelets present in the spleen.
Some diseases, besides ITP, drugs, and medicines can lead to the breakdown of platelets. An example is thrombotic thrombocytopenic purpura, which happens when blood clots are formed in the body. Several diseases are known to cause a decrease in platelets, including rheumatoid arthritis, lupus, leukemia, Gaucher's disease, aplastic anemia, quinidine, cirrhosis, lymphoma, and myelodysplasia.