A sedentary lifestyle can cause an individual to have a higher risk of developing colon cancer than one who has a more active lifestyle. A sedentary lifestyle is best defined as a type of lifestyle will very little or even no physical activity. The exact correlation between a sedentary lifestyle and colon cancer is not clear, but it is thought to be associated with the development of a metabolic disorder, inflammation, and adiposity accumulation.
Other factors can compound the sedentary lifestyle risk factor for colon cancer, such as insulin resistance, altered secretion of adipokines, and increased levels of sex hormones. A sedentary lifestyle also slows down an individual's metabolism and slows the movement of food through their gastrointestinal tract. Slowed digestive motility is known to produce chronic inflammation and intestinal tissue damage, which can increase an individual's risk of developing colon cancer.