15 Common Causes And Risk Factors For Septic Arthritis

Septic arthritis isn’t just painful—it’s potentially dangerous. This serious joint infection can strike when bacteria or other germs enter the bloodstream and settle into a vulnerable joint, or when an injury gives them direct access. While anyone can be affected, infants, older adults, and individuals with compromised immunity are especially at risk. The condition most often targets the knees but can also inflame hips, shoulders, and other joints. If left untreated, septic arthritis can rapidly destroy cartilage and bone, leading to permanent damage. That’s why early diagnosis and treatment—typically involving antibiotics and joint drainage—are critical. But how does this condition take hold in the first place? The answer often lies in overlooked triggers and subtle health factors. We’ve expanded our list to include 15 Common Causes and Risk Factors for Septic Arthritis—from chronic conditions and surgical risks to lifestyle habits and infections. Understanding them could be the key to prevention—and protection.

1. Various Types Of Infections

Septic arthritis can develop because of various types of infections, including fungal, viral, and bacterial infections. Staph infections, a common bacterial infection, are most often cited as the cause. These infections are unusually common because the bacteria can live and survive on both healthy and infected skin, so individuals are at risk of developing an infection regardless of their overall health. Usually, septic arthritis develops when infections from elsewhere in the body spread via the bloodstream, lodging in the joint. These might include common infections like urinary tract infections or skin infections. Joints are lined by a material called synovium, which isn't designed to protect itself against infections. Since the joint is so susceptible to infection, the body responds with an inflammatory and strong immune response that contributes to the joint damage through increased pressure and swelling.