An individual who has developed a pituitary tumor may also be affected by Carney complex, which is an inherited genetic condition that causes an individual to experience skin pigment issues, the development of myxomas, and endocrine system tumors. Tumors that develop in Carney complex patients may be malignant or benign. Carney complex is the result of a genetic mutation on the PRKAR1A gene inherited from the affected individual's parents in an autosomal dominant manner. In a small number of cases of Carney complex, the genetic mutation occurs spontaneously. The most common type of pituitary tumor that develops in individuals with Carney complex is called a growth hormone-producing pituitary adenoma. This type of tumor in the pituitary gland initially develops from the somatotropic cells or the cells in the pituitary gland responsible for producing growth hormone. This type of pituitary tumor causes the excessive production of IGF1 from the liver and can lead to acromegaly and gigantism.
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