Causes And Risk Factors Of Paget's Disease

Family History And Genetics

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Scientific evidence has proven there's a hereditary factor in the development of Paget's disease, as certain genes have been linked to the disorder. Approximately one-third of patients develop the disease because of family history and genetics. The condition tends to run in families, and at least twenty-five percent of patients have a family member also suffering from the condition. A mutation in a gene involved in the function of bone cells has been linked to forty to fifty percent of patients who inherited the disease. Viral infections may trigger Paget's disease in individuals with a genetic predisposition.

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