Diabetes And Insulin Resistance
Diabetes and insulin resistance can also contribute to biliary colic. In cases of both diabetes and insulin resistance, high low-density lipoprotein cholesterol is typical, along with elevated triglycerides. In addition, it may cause a drop in high-density lipoprotein cholesterol. According to research, these elements may trigger gallstone development.
Some research is also documented on elements that contribute to the rise in these lipids. Based on a 2008 study with mice, a protein called FOXO1 could be the explanation as to how insulin resistance and gallstones are linked. The study found the protein stimulated the secretion of cholesterol into the bile. As the mice were insulin resistant, they caused the protein to be reactivated. Gallstones developed as a result. A different study from 2008 suggests there is also a link with the enhancement of the expression of proteins Abcg5 and Abcg8. These proteins are widely shown to stimulate cholesterol secretion.
Learn more about what can increase the risk of biliary colic now.