Nonsteroidal anti-inflammatory medications can be useful for reducing pain while the peroneal tendons are healing. They reduce the swelling around the tendon, which reduces the amount of friction. During the initial weeks of healing, Nonsteroidal anti-inflammatories and ice packs to reduce swelling are often the best things patients can do for a minor injury. Stronger pain medication may be recommended in more severe cases, but opioids are almost never used for peroneal tendonitis. Topical creams are growing in popularity as a treatment for inflammation that avoids the potential side-effects of oral medications. Although in the beginning stages of research, platelet-rich plasma therapy is being studied as a possible treatment for peroneal tendonitis. This involves taking a small sample of the patient’s blood and spinning it a centrifuge until the healing factors and platelet-rich plasma are separated, after which the solution is injected directly into the problem area.
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