Due to the buildup of uric acid crystals, swelling often occurs. Generally starting in the big toe, associated swelling can quickly spread across the entire foot. This can make day-to-day activities challenging, especially for those who are on their feet during the workweek. As inflammation increases, swelling typically follows. You may also experience swelling within your ankles, knees, feet, elbows, and fingers. In some cases, swelling can spread into one’s calves. To find relief, apply cold compresses to inflamed areas.