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Overview Of Bupropion (Wellbutrin)

Bupropion, which is often sold under the brand Wellbutrin, is a prescription medication available as immediate-release and extended-release tablets. When the immediate-release tablets are used for depression in adults, doctors prescribe an initial dose of one hundred milligrams, and patients take two doses per day. The standard maintenance dose is three hundred milligrams per day. The maximum daily dose is four hundred milligrams. Patients with liver dysfunction may need to take a lower dose. Individuals with kidney issues could need dosing adjustments too. 

Bupropion is a significant part of depression treatment. Patients may only take this medication, though other treatments are often necessary. This medication may be pair with cognitive behavioral therapy for depression as well as mindfulness for depression. Of course, patients must understand this medication before taking it for the treatment of depression or other health conditions.

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How It Works

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Bupropion, an antidepressant, belongs to a group of drugs called aminoketones. In terms of its chemical structure, it is not related to tricyclic antidepressants, selective serotonin reuptake inhibitors, or other known antidepressants. However, some researchers classify it as a norepinephrine-dopamine reuptake inhibitor. This medication is structurally similar to diethylpropion and is soluble in water. This medication has a bitter taste and may produce numbness in the mouth during administration. 

It works by blocking the reuptake of dopamine and norepinephrine. Bupropion has also been shown to trigger the release of dopamine and norepinephrine from the presynaptic neuron. This medication is a non-competitive antagonist of the nicotinic acetylcholine receptors. As such, it binds to and activates these receptors. This mechanism can reduce cravings for nicotine.

Continue reading to reveal the uses for this medication next.

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