Potential Medication Interactions
Cyclosporine can inhibit CYP3A4. This is an enzyme responsible for removing toxins and drugs from the body. This means that taking it with certain medications can result in increased concentrations of these drugs or cyclosporine within the body that can be dangerous. The kidneys are highly susceptible because their excretion rate of harmful substances is decreased. This can cause toxins and metabolites to build in these organs. Other medications that cyclosporine has been known to interact with include antivirals, antibiotics, steroids, blood pressure medications, and cholesterol drugs. Examples include cidofovir, neomycin, mifepristone, bosentan, and atorvastatin.
Taking high doses of methylprednisolone in combination with cyclosporine has been linked to neurotoxicity. This can result in convulsive seizures in some individuals. As cyclosporine is known to cause reductions in magnesium, other magnesium-reducing medications may also cause serious interactions when taken with it. It is important that patients speak to their doctor before taking this drug. This will help prevent potential medication interactions.