Guide To Dapsone (Aczone)

Dapsone is part of a group of medicines called sulfones. It is available by prescription. The medication was first used for the treatment of leprosy in the 1940s. Typically, patients with acne are prescribed the topical form. Individuals with leprosy or dermatitis herpetiformis take it orally. The standard daily dose for tuberculoid leprosy is one hundred milligrams. Patients will need to take it for up to six months. Individuals with dermatitis herpetiformis begin on a dose of fifty milligrams daily. The dose may reach up to three hundred milligrams. Generally, these patients must continue to take dapsone for the rest of their lives. Patients will need regular monitoring and laboratory tests during their treatment.

As mentioned, topical dapsone is a common prescription acne treatment. Doctors also prescribe it as a leprosy treatment for certain forms. When used for acne, patients often apply it as a topical cream. However, there are other antibiotics for acne, both topical and oral antibiotics. Patients may need to take oral dapsone with other medications to prevent antibiotic resistance. Ultimately, it is vital to understand how this medication works before taking it.

How It Works 


Dapsone, which can be sold as Aczone, is a sulfone antibiotic. It stops bacteria growth by blocking the synthesis of dihydrofolic acid, a vitamin B9 derivative. The synthesis is blocked through the creation of competition with PABA. Dapsone is also an anti-inflammatory medication. It blocks the action of an enzyme called myeloperoxidase. The blockage means that hypochlorous acid cannot accumulate in the body. This mechanism reduces the tissue damage that occurs as a result of inflammation. Some researchers believe that this blockage may also reduce the inflammation associated with neurodegenerative conditions. Examples include strokes and Alzheimer's disease. 

Continue reading to uncover information on the uses and benefits of this medication next.

Emily Fowler