Midodrine is used to treat orthostatic hypotension. This condition involves a sudden drop in blood pressure when an individual stands up from a sitting position. This medication is an alpha-adrenergic agonist. It stimulates the nerve endings in the patient's blood vessels. The blood vessels tighten, and the patient's blood pressure increases. This medication's side effects include stomach pain, frequent urination, chills, and a tingling sensation on the skin. Less commonly, individuals taking this medicine have reported leg cramps, insomnia, dry mouth, drowsiness, and dizziness.
Most patients will need to take midodrine three times per day. Patients should take each dose at least three hours apart and the last dose before 6 p.m. Since this medicine increases the patient's blood pressure while they are lying down, they should not take it near bedtime or before a nap. Doctors may recommend that patients raise the head of their bed for rest or sleep. Midodrine may interact with alpha-blockers and beta-blockers. To reduce the risk of interactions, patients should let their doctors know about all of the medicines and supplements they use.
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