Calcium Channel Blockers
Increases in calcium strengthen the force of contractions in both the heart and blood vessels. Calcium channel blockers, which relax the muscles of the blood vessels, also reduce a patient's heart rate, and as a result, the patient's blood pressure decreases. Some of the most common options include amlodipine, diltiazem, clevidipine, isradipine, nisoldipine, and verapamil hydrochloride.
Calcium channel blockers may also work better for seniors and those of African heritage than using ACE inhibitors alone. It should be noted that grapefruit juice interacts with some forms of calcium channel blockers, increasing blood levels of the medication and putting the patient at a higher risk of complications. Thus patients should be wary of consuming grapefruit juice when taking this medication