What Increases The Risk Of Chondrosarcoma?

Paget's Disease

Paget's disease is a disorder of the bones that causes problems with the body's normal bone remodeling process. In healthy individuals, the body absorbs old bone, and it forms new healthy bone in place of it. Individuals affected by Paget's disease have a malfunction in their bone remodeling process. The body of these individuals tends to generate too much new bone tissue in the wrong locations, or it may remove old bone from the areas where new bone should go. Paget's disease tends to be caused by mutations of the genes passed through families.

Because Paget's disease causes an individual to regenerate more bone then they typically would, the DNA of these bone cells undergo more changes on average than in a healthy individual. More DNA changes in bone cells increase the risk of mutations occurring in the part of the cell's DNA that controls cellular growth, replication, and cellular death. When certain mutations are made in these sections of the cell's DNA, chondrosarcoma will begin to develop.