10 Alarm-Ringing Signs Your Body Might Be Battling Hemolytic Uremic Syndrome

5. Extreme Fatigue

When an individual develops hemolytic uremic syndrome, it means more red blood cells are being destroyed than made. This imbalance is what causes low red blood cell counts and characterizes a condition referred to as hemolytic anemia. Red blood cells are what carry oxygen molecules around the body to the cells so they can carry out their differentiated and respective functions. When there are not enough red blood cells in circulation because of hemolytic uremic syndrome, the cells in the body do not receive enough oxygen. Cells require oxygen and glucose to carry out the metabolic process that produces usable cellular energy (ATP). A shortage of oxygen causes a shortage of ATP in the cells, which induces an adaptive response by the body to allocate the little bit of energy it has to the most important tissues like the brain and heart. This reallocation of cellular energy is what makes an individual feel extreme fatigue when they are affected by hemolytic uremic syndrome.

6. Pale Skin

Pale skin is a hallmark symptom of hemolytic uremic syndrome due to the destruction of red blood cells, which leads to hemolytic anemia. Red blood cells are responsible for giving the skin its healthy, rosy hue by delivering oxygen to tissues. When these cells are destroyed faster than the body can replace them, the skin may take on a pale or ashen appearance. This symptom is often more pronounced in areas such as the face, hands, and lips. The breakdown of red blood cells also leads to decreased oxygen delivery to tissues, further exacerbating the pale complexion. If untreated, pale skin can be accompanied by additional signs of anemia, including dizziness and weakness. Treatment of the underlying cause, such as red blood cell transfusions or dialysis, can help alleviate this symptom by restoring proper oxygenation and circulation.