10 Potential Causes And Risk Factors For An Enlarged Spleen
10. Felty's Syndrome: Rheumatoid Arthritis's Rare Complication

Felty's Syndrome is a rare, severe complication of rheumatoid arthritis that uniquely involves an enlarged spleen. This isn't just general arthritis; it's a specific manifestation where chronic rheumatoid arthritis, often severe and long-standing, leads to splenomegaly along with a dangerously low white blood cell count (neutropenia). The enlarged spleen plays a role in destroying white blood cells, leaving the individual highly vulnerable to infections. This specific triad of symptoms (RA, splenomegaly, neutropenia) signals a complex autoimmune response demanding specialized rheumatological and hematological management.