10 Potential Causes And Risk Factors For An Enlarged Spleen

Lisette Marie

7. Leukemia: Blood Cancer's Hidden Impact

Bald Woman Receiving Chemotherapy Treatment. Photo Credit: Envato @seventyfourimages

Similar to lymphoma, various types of leukemia, particularly chronic leukemias (like CML or CLL), frequently cause splenomegaly. This occurs when cancerous white blood cells proliferate excessively in the bone marrow and then spill into the bloodstream and organs, including the spleen. The spleen then swells as it attempts to filter these abnormal cells. This enlargement can be a key diagnostic clue, often accompanied by other subtle symptoms like fatigue, unexplained bruising, or recurrent infections, signaling a serious underlying blood cancer demanding urgent hematological assessment.

8. Sarcoidosis: Systemic Inflammation's Splenic Touch

Female doctor holding Lungs in hand on right side.Healthcare hospital service concept stock photo. Photo Credit: Envato @nuttapong_mohock

Sarcoidosis, a baffling inflammatory disease, can ingeniously cause an enlarged spleen. This condition involves the growth of tiny, inflammatory cell clusters (granulomas) in various organs, including the spleen. While sarcoidosis often affects the lungs and lymph nodes, splenic involvement is common, leading to enlargement as the spleen's tissue is infiltrated. This non-infectious, systemic inflammation can lead to a palpable spleen, often without other obvious symptoms, making it a subtle but crucial warning sign of a widespread inflammatory disorder.

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7. Leukemia: Blood Cancer's Hidden Impact

8. Sarcoidosis: Systemic Inflammation's Splenic Touch

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