10 Potential Causes And Risk Factors For An Enlarged Spleen

9. Amyloidosis: Protein Deposits' Silent Strain

Amyloidosis is a rare, complex condition where abnormal proteins (amyloid) build up in organs, including the spleen. This isn't just a simple swelling; it's a profound infiltration that gradually stiffens and enlarges the spleen as the amyloid protein deposits accumulate. The insidious nature of amyloidosis means symptoms are often non-specific and develop slowly, making an enlarged spleen a potentially early, critical clue. This type of splenomegaly points to a systemic protein disorder that can severely impact organ function throughout the body if left undiagnosed.