11 Early Warning Signs Of Plummer-Vinson Syndrome

5. Burning Sensations

Patients with Plummer-Vinson syndrome might experience burning sensations across several areas of the body. The iron deficiency associated with this condition is known to cause burning sensations on the tongue, and some patients who are low in iron have reported tingling or burning sensations in their arms and legs. Burning sensations on the outer corners of the mouth may be present if the patient has angular cheilitis as a result of Plummer-Vinson syndrome. Individuals with this syndrome who also have gastroesophageal reflux disease (GERD) may experience heartburn and a burning sensation in the mouth or throat, and these sensations may worsen if esophageal strictures develop. Depending on the area where the burning sensation occurs, patients may be able to experience relief from this sensation through iron supplementation, treatment for angular cheilitis, avoidance of spicy foods, and esophageal procedures to treat strictures.

6. Brittle or Spoon-Shaped Nails (Koilonychia)

Koilonychia, also known as "spoon nails," is a hallmark sign of iron deficiency and a common physical manifestation in individuals with Plummer-Vinson syndrome. This condition causes the nails to become thin, brittle, and concave—often curving upwards at the edges, resembling a spoon. The texture may feel soft or rough, and nails may break easily or develop ridges. While nail changes might seem minor compared to other symptoms, they serve as important external clues that can help prompt early investigation into underlying iron-deficiency anemia. In some cases, the nails may also appear pale or take longer to grow. Treatment typically involves correcting iron levels through supplementation or dietary changes. As iron levels improve, nail health often gradually returns to normal. If you notice unusual changes in your nails—especially spoon-like indentations—bring them to your doctor’s attention, as they may be one of the earliest signs your body is lacking vital nutrients.