11 Early Warning Signs Of Plummer-Vinson Syndrome

7. Difficulty Speaking or Hoarseness

Beyond interfering with swallowing, the esophageal webs associated with Plummer-Vinson syndrome can also subtly affect vocal quality. These webs may alter the shape and flexibility of the upper esophagus, leading to irritation or pressure near the larynx (voice box). As a result, some individuals report persistent hoarseness, a scratchy or weak voice, or a sensation of tightness in the throat, especially after speaking for long periods. These vocal changes may not be immediately attributed to a physical cause and are often overlooked or mistaken for allergies or postnasal drip. However, in patients with other signs of iron deficiency or trouble swallowing, vocal strain can be a valuable diagnostic clue. Treatment that addresses iron-deficiency anemia and resolves the structural issues in the esophagus—such as dilation of webs—often leads to noticeable improvement in vocal strength and clarity. If voice changes persist, an ENT specialist may perform a laryngoscopy to assess the area more closely.

8. Chest Discomfort or Palpitations

Iron-deficiency anemia, a hallmark of Plummer-Vinson syndrome, can lead to reduced oxygen delivery throughout the body. To compensate, the heart often works harder and faster, which can cause symptoms such as chest tightness, fluttering sensations, or heart palpitations. Patients may describe their heartbeat as irregular, pounding, or skipping—a sensation that can be alarming and is frequently misattributed to panic or anxiety attacks. In more severe cases, shortness of breath or lightheadedness can accompany these cardiovascular symptoms. Since chest discomfort is a red flag for more serious heart conditions, it's important for patients to seek medical attention promptly to rule out life-threatening issues. A full blood panel, including hemoglobin and ferritin levels, can help determine if the root cause is iron deficiency. Fortunately, in many cases, iron supplementation helps normalize heart function and significantly reduces palpitations. Nonetheless, persistent symptoms may warrant an electrocardiogram (ECG) or echocardiogram for a deeper evaluation of heart health.