12 Early Warning Signs of Cushing Syndrome To Never Ignore

2. Unexplained Weight Gain: A Telltale Sign

One of the earliest and most noticeable signs of Cushing Syndrome is unexplained weight gain, particularly around the abdomen, face, and neck. This weight distribution is often disproportionate, with limbs remaining slender. The accumulation of fat in these areas is due to cortisol's effect on fat storage and distribution. Patients may notice a "moon face" or a "buffalo hump" – a pad of fat between the shoulders. This symptom can be distressing and is often mistaken for normal weight gain, delaying diagnosis. Recognizing this pattern of weight gain is crucial, as it often serves as a visual cue for further investigation into Cushing Syndrome.