18 Hidden Causes of High Neutrophil Counts That Doctors Want You to Know

15. Obesity and Metabolic Syndrome

Excess body fat, particularly visceral fat around the organs, is not just a passive storage site—it actively releases inflammatory molecules that contribute to chronic low-grade inflammation in the body. This inflammatory state stimulates the bone marrow to produce more neutrophils, leading to neutrophilia in some individuals with obesity or metabolic syndrome. Metabolic syndrome, a cluster of conditions that includes high blood pressure, insulin resistance, and abnormal cholesterol levels, is strongly associated with increased neutrophil counts. Research suggests that chronic inflammation in overweight individuals may contribute to the development of type 2 diabetes and cardiovascular disease. The good news is that weight loss and improved metabolic health through lifestyle changes—such as better diet, exercise, and stress reduction—can help lower neutrophil levels, reducing the risk of long-term complications.