18 Hidden Causes of High Neutrophil Counts That Doctors Want You to Know

16. Periodontal Disease (Gum Infections)

Your oral health and immune system are more closely linked than you might think. Periodontal disease, a severe form of gum infection caused by bacteria, can lead to persistent neutrophilia. When bacteria accumulate along the gum line, they trigger an immune response, recruiting neutrophils to the site of infection. If left untreated, the infection becomes chronic, leading to ongoing inflammation and an excess of circulating neutrophils in the bloodstream. Studies have shown that individuals with advanced periodontal disease often exhibit elevated white blood cell counts, including neutrophils, even if they do not have other obvious signs of systemic illness. Regular dental check-ups, proper oral hygiene, and treating gum disease early can help prevent prolonged immune activation and its associated risks, including heart disease and diabetes.