Signs Of Alport Syndrome

Edema

Edema occurs when the feet, ankles, legs, and area around the eyes become swollen as a result of abnormal fluid accumulation. The exact symptoms will vary depending on the type of edema the patient is suffering. Symptoms of the peripheral version tend to include swelling of whatever areas are affected, and the surrounding skin will tighten. Swelling tends to be gravity-dependent, meaning it will change depending on the body's position. When a patient is upright, the swelling may increase; when they keep their legs elevated, it may decrease in the legs but appear more prominently in their eyes. The skin around the swollen area will look shiny and tight. If a person applies pressure with their finger, an indentation will often appear.

This symptom occurs with Alport syndrome because the capillaries in the body have leaked blood into their surrounding tissue, and the excess fluid causes the swelling. Fluid leaking from the blood vessels is caused because of abnormalities in the body's collagen production. The collagen is necessary to regulate their blood vessels correctly.