Common Causes, Risk Factors, And Complications Of Amyloidosis

Abnormal Antibodies In Bone Marrow

Amyloid proteins are created in the bone marrow. Amyloidosis occurs when certain cells, called plasma cells, create abnormal antibodies in bone marrow. These then enter the bloodstream and leave excessive deposits of amyloid, which then lead to a buildup and blockage. Normal, healthy bodies have these chains of proteins and antibodies in their blood. In fact, they help to protect the body from many infections and illnesses. However, these abnormal chains clump together in a way not easily cleared away by the body. Over time, these clumps build up as deposits in the tissues and organs, which impedes their ability to function and gradually stops them altogether.