Common Causes Of White Matter Disease
Older Age

Individuals of an older age appear to be at a higher risk of developing white matter disease than those who are younger. In fact, since white matter disease is categorized as an age-related disease, it's rare for it to affect younger populations. Another factor adding to this is the progression of white matter disease. Many symptoms don't become noticeable until the disease is fairly advanced, which can take some time. The symptoms may also be subtle enough at first to be ignored. Age is the most common risk factor, and an individual's risk increases when they reach middle age, and becomes much higher as they get older.
Smoking

There are multiple studies indicating smoking can increase an individual's chance of developing white matter disease, especially as they get older. One reason for this may be that smoking greatly increases an individual's risk of developing heart disease, which in turn increases their chances of neurological issues. In one study, twenty-three percent of smokers had signs of white matter disease progression. Those who smoked more had a higher risk of developing the disease than those who smoked less. This means if an individual reduces the amount they smoke, even if they don't fully quit, they will lower their risk of developing white matter disease. With that said, the best way to avoid the many health risks associated with smoking is to stop smoking fully.