Common Symptoms Of Mastocytosis

Nausea And Vomiting

Mast cells are responsible for causing symptoms in an individual's gastrointestinal system. These cells are critical immune system cells produced by the bone marrow that attack pathogens and release substances to eliminate any threat to the body. Mastocytosis patients experience higher levels of mast cells in their bodies than healthy individuals. Mast cells that detect an allergen release histamine, which causes swelling and redness of the affected area, producing inflammation. An individual who experiences inflammation of the nerves near the stomach and other digestive structures can experience nausea and vomiting as a result of the activation of the nausea center in the brain. Histamine is known to increase the production of gastric acid by the stomach, which can also cause nausea. Mast cell infiltration of the blood and digestive tract can result in hematological abnormalities. Some hematological abnormalities can make the patient prone to bleeding in their stomach and other parts of the gastrointestinal tract. Blood in the digestive tract serves as an irritant, and its presence can induce nausea and vomiting.

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Enlarged Spleen Or Liver

The liver is a large organ that helps clear toxins and waste products from the blood. The spleen is a lymphatic system organ that also serves to remove dead cell parts and wastes from the blood so they can be excreted in the stool and urine. Because mast cells are large cells, they can leave less room for components of the blood to circulate properly. This mechanism can produce portal hypertension, or an increased blood pressure level in the veins that make up the portal venous system. The portal venous system is the network of vessels that allow blood to flow throughout the liver. The accumulated mast cells in the blood can accumulate in the portal venous system as the liver tries to remove them from the blood. The spleen also becomes enlarged when it takes on a buildup of mast cells it is also trying to filter from the blood. Inflammation that occurs in the liver can cause the swelling of the spleen and vice versa because of their proximity to each other.

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