Most Common Types Of Cancer Found In Li-Fraumeni Syndrome

Acute Leukemia

Li-Fraumeni syndrome patients are at a higher risk of developing a type of blood cancer referred to as acute leukemia. When a mutation occurs in the DNA of cells in an individual's bone marrow that causes them to grow and multiply out of control, it is called leukemia. Acute leukemia is a type of leukemia that spreads and grows rapidly without appropriate treatment. Recurring infections, low white blood cell counts, pale skin, fever, joint aches, easy bruising, night sweats, breathlessness, fatigue, bone aches, and petechiae are all acute leukemia symptoms.

Li-Fraumeni precipitated acute leukemia is diagnosed with the use of blood tests and bone marrow biopsy. Targeted therapy, chemotherapy, and stem cell therapy can be utilized to treat acute leukemia. Treatment for this type of blood cancer must be aggressive and intense to eliminate the cancerous cells in the body successfully. Li-Fraumeni syndrome patients have frequent blood tests to improve their odds of early detection should they develop this form of cancer.

Brain Cancer

Brain cancer is a malignancy that originates in the cells that make up brain tissue. There are numerous types of brain cancer, but some of the most common include medulloblastomas, meningiomas, acoustic neuromas, ependymomas, craniopharyngiomas, brainstem gliomas, and astrocytoma. Symptoms that occur with brain cancer can vary depending on its type.

Generalized symptoms include headaches, nausea, vomiting, peripheral sensation loss, balance problems, problems with speech, confusion, impaired hearing, seizures, behavioral changes, personality changes, vision problems, and vomiting. MRI scans, neurological examination, CT scan, PET scan, and brain biopsy can be utilized to make a brain cancer diagnosis. Li-Fraumeni syndrome patients may decide to have MRI scans periodically to increase their chances of early detection.