Esthesioneuroblastoma: 10 Critical Symptoms You Need to Know

7. Facial Numbness or Weakness

As esthesioneuroblastoma infiltrates beyond the immediate nasal cavity, it can impinge upon or damage adjacent cranial nerves. A subtle but critical symptom is **unexplained facial numbness, tingling, or even a noticeable weakness on one side of the face.** This might manifest as difficulty with facial expressions, a drooping eyelid, or altered sensation around the nose or cheek. This indicates the tumor is affecting the trigeminal or facial nerves, signaling a more advanced local spread. Such neurological changes are rarely benign and warrant immediate investigation to identify the underlying cause, especially when combined with other nasal or ocular symptoms.

8. Changes in Voice or Difficulty Swallowing

When esthesioneuroblastoma grows significantly downwards or spreads more broadly, it can subtly impact the throat and vocal cords. Patients might notice **a persistent hoarseness, a change in voice quality, or even mild difficulty swallowing (dysphagia).** This occurs if the tumor creates a mass effect that irritates or presses on the pharynx or larynx, or if advanced disease affects nerves controlling these functions. While these symptoms can have many causes, their unexplained and progressive nature, especially when combined with nasal symptoms or headaches, should prompt a comprehensive ear, nose, and throat (ENT) evaluation.