Esthesioneuroblastoma: 10 Critical Symptoms You Need to Know

9. Hearing Changes or Tinnitus

Beyond direct ear pain, esthesioneuroblastoma can manifest as **unexplained changes in hearing, including muffled sounds, a feeling of fullness in one ear, or persistent ringing (tinnitus).** If the tumor extends into the sphenoid sinus or affects the Eustachian tube, it can disrupt pressure equalization in the middle ear, leading to hearing abnormalities. More seriously, direct invasion into the temporal bone or auditory nerves can cause these symptoms. Any unilateral or sudden onset of hearing issues, without obvious infection, warrants careful investigation as a potential indicator of tumor growth.

10. A Palpable Lump on the Face or Neck

While ENB originates internally, in very advanced stages, or with specific patterns of spread, it can manifest as a **palpable lump or swelling on the face (e.g., cheek, forehead) or in the neck (e.g., enlarged lymph nodes).** A facial lump indicates the tumor has grown significantly enough to push outwards through the bone, or has created a visible deformity. A neck lump, particularly if firm and non-tender, suggests metastatic spread to regional lymph nodes. These external signs are serious indicators of advanced disease and demand immediate medical attention as an urgent sign of potential widespread cancer.