What Causes Restless Leg Syndrome?

Anemia And Iron Deficiency

A fifth condition associated with increased risk of rest leg syndrome is anemia and iron deficiency. Several factors have long indicated the link between iron levels and restless leg syndrome. First, researchers have found iron levels in the body naturally decrease during the night, a condition called the circadian variation. This corresponds with the time most restless leg syndrome symptoms occur. Third, pregnant women have an increased risk of restless leg syndrome during the last trimester, when the mother's iron levels are low.

Medical conditions such as these have helped researchers discover the important role of iron in restless leg syndrome. "The brain iron insufficiency in patients with RLS is now well established," concluded Richard Allen, a professor in the Department of Neurology at Johns Hopkins University. Researchers believe low iron levels interfere with the action of dopamine in the brain, which leads directly to restless leg syndrome. Two recent studies found iron supplementation significantly reduces the symptoms of restless leg syndrome.

Allergy Medication

Many individuals who suffer from allergies, particularly those of the seasonal variety, tend to take antihistamines, especially drowsy ones, to get rid of symptoms such as a runny nose and sneezing, so they can be more comfortable and get some rest. Unfortunately, however, reports indicate drowsy antihistamines can actually worsen the symptoms of restless leg syndrome and make it even more difficult to fall and stay asleep. While the exact reason for this is unknown, some research indicates antihistamines that do not cause drowsiness don't affect restless leg syndrome as much simply because this medication does not enter the brain as easily. In any case, individuals dealing with allergies as well as restless leg syndrome should turn to other options for allergy relief than antihistamines.