The 7 Stages Of Alzheimer's Disease
11. Profound Confusion and Loss of Independence
Stage Six — As Alzheimer’s disease progresses to stage six, the ability to recognize familiar surroundings, faces, and routines fades, leading to severe disorientation and confusion. Patients may no longer recognize close friends and family members except for those they see most often. Drastic personality changes, agitation, and unpredictable behaviors—such as aggression, paranoia, or emotional outbursts—become common. Many individuals experience loss of bladder and bowel control, making full-time assistance necessary. Wandering is also a significant concern, as patients may attempt to leave home, unaware of where they are going or why. At this stage, full-time supervision and professional caregiving are essential, as patients require help with bathing, dressing, eating, and using the bathroom. With the increasing loss of cognitive function, safety becomes a top priority.
12. The Importance of Comfort and Familiarity

Stage Six — Once Alzheimer’s reaches stage six, maintaining a calm and familiar environment becomes essential. Loud noises, new environments, or disruptions in routine can be extremely distressing, sometimes triggering agitation or aggression. Familiar objects, soothing music, and consistent caregiving can help reduce anxiety. Caregivers may also notice a phenomenon known as "sundowning," where confusion and restlessness intensify in the late afternoon or evening. Strategies such as increasing exposure to natural light, maintaining predictable schedules, and reducing caffeine intake can help ease this symptom.