The Autoimmune-Skin Connection: 9 Subtle Changes You Can't Ignore

7. Purple or Red Lines (Livedo Reticularis)

A network of purplish or reddish lines, almost resembling delicate lace or a fading bruise, sometimes appears on the skin—usually on the legs, forearms, or trunk. This is called livedo reticularis, and while it can be triggered by cold weather or brief changes in blood flow, its persistent presence can be associated with autoimmune conditions like lupus or other rheumatic diseases. These patterns often come and go, and they’re usually painless, but they can be unsettling if you haven’t noticed them before. The important thing isn’t to panic, but to stay curious—especially if they stick around, deepen in color, or appear alongside other changes. Snap a photo as a visual record and let your provider know. Every pattern tells a story, and livedo reticularis, in particular, offers another chance to listen compassionately to your body.

8. Non-Healing Sores or Ulcers

No one likes finding a sore that just won’t go away, whether it’s in the mouth, on the legs, or along your fingers. When these spots take longer than expected to heal, keep reopening, or refuse to close completely, they may be signaling immune system confusion. Though everyone sometimes deals with small cuts or canker sores, ulcers that linger for weeks can point to deeper inflammation or changes in blood flow commonly seen in certain autoimmune conditions. Instead of self-blame or frustration, acknowledge your body’s attempt to alert you and reach out to a care provider. Documenting how long the sore has lingered, any swelling or pain, or changes in color can help guide your provider toward helpful solutions. Remember: Noticing doesn’t equal panic. It’s an act of wisdom and care, opening pathways to better support and healing.