Insulin: Major Causes Of Resistance And Why

Obesity

A diet high in refined carbohydrates, processed foods, and sugar may lead to obesity, which is widely associated with an increased risk of insulin resistance. According to a 2012 study, prolonged exposure to a high amount of fatty acids may lead to insulin resistance. Saturated fatty acids, such as stearic and palmitic acids, were found to the most potent cause of insulin resistance. The study went on to state fatty acids impair insulin actions by creating oxidative stress, modulating gene transcription, and causing mitochondrial dysfunction and inflammation.