Signs Your Gut Microbiome is Out of Whack (And How to Fix It)

15. Hormonal Imbalances or Irregular Cycles

Your gut plays a surprisingly central role in hormone regulation—especially estrogen. The estrobolome, a subset of gut bacteria, helps metabolize and eliminate excess hormones. When these microbes are disrupted, it can lead to estrogen dominance, irregular periods, PMS symptoms, or skin breakouts. Hormonal fluctuations aren’t always caused by reproductive organs alone—they often begin in the gut. To support balance, increase fiber (to bind and excrete excess estrogen), avoid processed foods, and eat cruciferous vegetables like broccoli and cauliflower. Adding fermented foods and reducing endocrine disruptors (like plastics) can further stabilize hormone levels through microbiome support.

16. Intolerance to Stress or Overreactive Responses

If small stressors now feel overwhelming, your gut might be amplifying the response. The microbiome influences cortisol levels and nervous system sensitivity. Dysbiosis can trigger an exaggerated stress response, leading to anxiety, irritability, or emotional exhaustion. It’s a feedback loop: stress harms gut health, and poor gut health worsens stress resilience. Breaking the cycle starts with nourishment—prioritize gut-calming foods like oats, bone broth, and fermented veggies. Probiotic supplements and mindfulness practices (like breathwork or meditation) can also reduce inflammation and help recalibrate the gut-brain axis for better emotional balance.