13 Serious Problems That Hives Could Indicate
Vitiligo

Vitiligo is a skin disease resulting in loss of color in patches and is caused when melanin-producing cells in the hair, skin, and eyes, die off. Doctors think one of the causes may be related to an attack by the immune system on the skin’s melanocytes. As a result, these blotches can occur either localized or all over the body. Hives occur when the immune system tries to attack what it thinks is an allergen so the itchy, red condition can show up in people with vitiligo.
Pernicious Anemia

Pernicious anemia occurs mainly due to a vitamin B12 deficiency. The body lacks the ability to produce enough red blood cells for optimal health. Studies have shown a connection between autoimmunity in chronic hives and a lack of vitamin B12. In 2004, one such study indicated thirty-three percent of patients with chronic hives had a B12 deficiency and along with autoimmune urticaria (hives), were affected by autoimmune thyroiditis. It is not the main symptom of Pernicious anemia.
