12 Longevity Clinics and Treatments That Aim to Extend Human Lifespan

5. NAD+ and metabolic therapies

NAD+ supplements and IV therapy have become popular in some longevity circles because NAD+ is a key metabolite tied to cellular energy and repair. Clinics offering NAD+ infusions often pair them with metabolic reset programs—diet guidance, exercise prescriptions, and hormone optimization. The biological rationale is plausible: NAD+ levels decline with age, and boosting them may improve cellular resilience. Clinical evidence, however, is mixed. Some small studies show metabolic or subjective benefits, while larger, long-term trials connecting NAD+ therapies to meaningful lifespan or major disease outcomes are still limited. Cost is a practical consideration—IV regimens and ongoing infusions can add up quickly with unclear return on investment. For patients, an evidence-first approach helps: prioritize lifestyle changes with proven benefits, view NAD+ as a potential adjunct, and ask any clinic for trial data, expected benefits, and clear monitoring protocols. If the clinic recommends frequent IVs, ask about sterility procedures, medical oversight, and whether less invasive NAD+ boosters have been considered first.

6. Stem-cell–based interventions

Stem-cell therapies cover a broad range of approaches, from FDA-approved uses like certain bone marrow transplants to less-regulated offerings for joint pain, cosmetic issues, or broader “rejuvenation” aims. Many clinics promote mesenchymal stromal cell (MSC) injections for tissue repair or immune modulation; the quality of evidence varies by indication. Where strong randomized trials exist, clinicians can recommend cell therapies with confidence. Where evidence is thin, patients may pay for interventions that deliver unclear benefit and bear potential safety risks like infection or aberrant tissue growth. Regulation matters: in the US, the FDA scrutinizes claims and may require an approved pathway for most stem-cell products. Ask a clinic whether a therapy is FDA-approved for your condition, whether the offering is part of a clinical trial, and to see peer-reviewed data. Also request details on cell sourcing, processing, sterility, and follow-up plans. When used appropriately and transparently, stem-cell treatments can be powerful. When used prematurely, they risk harm and costly disappointment.