17 Gastro Gaffes: When Ignoring GERD Gets Gravely Gutsy

13. Increased Risk of Esophageal Cancer

Barrett’s esophagus—a known complication of chronic GERD—can significantly increase the risk of esophageal adenocarcinoma. Although most people with GERD won’t develop cancer, long-standing reflux can lead to cellular changes in the esophagus that become precancerous. Regular monitoring with endoscopy and biopsies is recommended for patients with Barrett’s esophagus. Early detection of dysplasia (abnormal cells) allows for prompt intervention and may prevent the progression to cancer. Lifestyle changes and aggressive acid suppression therapy are key to reducing this risk.

14. Globus Sensation

Globus sensation is the persistent feeling of a lump or tightness in the throat—despite no actual obstruction. Though not painful, it can be distressing and is often linked to GERD-induced inflammation of the throat and upper esophagus. Unlike dysphagia, it does not involve difficulty swallowing. It may worsen with stress or frequent reflux episodes. Treating the underlying GERD usually improves symptoms. Patients are also advised to avoid throat clearing, which can further irritate the tissue.