Often-Missed Symptoms Pointing Towards Autoimmune Disease

25. Chronic Hives or Itchy Welts: Skin Speaking Up

If you’re frequently breaking out in hives that come and go without an allergy trigger, your immune system may be sounding the alarm. Chronic idiopathic urticaria—hives with no clear cause—has been linked to autoimmune thyroid disease and lupus. These welts often appear suddenly, itch intensely, and fade within hours—only to return somewhere else. Antihistamines might mask the symptoms, but they don’t address the root. When your skin repeatedly erupts without reason, it’s worth asking whether your immune system is misreading harmless cells as threats. Your body may be itching to get your attention—literally.

26. Cracking or Ulcers in the Corners of the Mouth: Micronutrient Misfire

Persistent cracks, sores, or inflammation at the corners of your mouth—known as angular cheilitis—can be more than just dry lips. Autoimmune diseases like celiac or Crohn’s can impair nutrient absorption, especially of B vitamins and iron, leading to these subtle oral symptoms. Fungal overgrowth may also occur due to immune dysregulation. If your lips feel sore, tight, or crack repeatedly despite using balms and staying hydrated, check your nutritional status. Sometimes, the immune system’s battle inside your gut shows up right at the edge of your smile. It’s a small sign with a big backstory.