Medications That Could Be Contributing to Your Weight Gain
19. Opioids: Pain Relief with Metabolic Effects

Opioid medications like oxycodone, hydrocodone, and morphine are prescribed for severe pain but can cause unexpected weight gain due to slowed metabolism, water retention, and fatigue. Additionally, opioids may alter gut bacteria and hormone regulation, leading to increased cravings for carbohydrates and high-calorie foods. What to Do: If using opioids long-term, work with your doctor on gradual dose adjustments or alternative pain relief strategies. Staying hydrated and incorporating fiber-rich foods can help prevent bloating and digestive issues.
20. Estrogen Therapy: Hormonal Weight Shifts

Hormone replacement therapy (HRT) for menopause or hormonal imbalances can sometimes lead to fluid retention and fat redistribution, particularly around the abdomen and thighs. While estrogen therapy itself doesn’t directly cause weight gain, it may slow metabolism and increase appetite due to shifts in hormone levels. What to Do: Focus on strength training, protein-rich meals, and hydration to maintain a stable metabolism. If weight gain becomes a concern, talk to your doctor about adjusting HRT dosage or exploring lifestyle modifications.