Medications That Could Be Contributing to Your Weight Gain

33. Oral Contraceptives: The Hormonal Puzzle

Many oral contraceptives contain both estrogen and progestin. While some people may experience weight gain from fluid retention and increased appetite, the effect is often dependent on the specific type of progestin used. Some progestins have a stronger androgenic effect, which can increase insulin resistance and lead to more significant weight gain. Others may have little to no effect. The emotional and physical stress of starting a new hormonal medication can also disrupt appetite and metabolism. If you are experiencing weight changes, it is worthwhile to discuss with your doctor whether a different formulation or a non-hormonal option is a better fit for your body, rather than assuming all birth control is the same.

34. Antiretroviral Therapy (ART) for HIV: The Metabolic Trade-Off

While the older generation of HIV medications often caused lipodystrophy (fat loss in some areas and fat accumulation in others), newer integrase inhibitors like dolutegravir have been associated with more general weight gain. The exact mechanism is not fully understood, but research points to changes in appetite regulation, fat distribution, and metabolic shifts. This weight gain, especially in the abdominal area, can increase the risk of developing insulin resistance and cardiovascular issues. Managing this side effect requires a multi-pronged approach. Regular check-ins with your healthcare provider to monitor metabolic health, a consistent exercise routine (including both cardio and strength training), and a diet focusing on whole foods can help manage weight while maintaining an effective HIV treatment plan.