Medications That Could Be Contributing to Your Weight Gain

35. Antihypertensive Vasodilators: A Deeper Look

Vasodilators like hydralazine and minoxidil widen blood vessels to lower blood pressure, which is great for your heart. However, this widening can cause your kidneys to think your blood volume is low, triggering them to hold onto more salt and water. This isn't fat gain, but it can cause significant fluid retention, leading to a bloated feeling and an increase on the scale. For people with chronic conditions, this can be especially frustrating and make them feel like their efforts to stay healthy are failing. The best way to combat this is to limit your sodium intake, stay well-hydrated, and, if the problem persists, discuss with your doctor whether a diuretic (a "water pill") is needed to help your body flush out the excess fluid.

36. Pain Management with Tricyclic Antidepressants (TCAs)

Medications like amitriptyline are often a first-line treatment for nerve pain, migraines, and fibromyalgia. However, their pain-relieving effects are often accompanied by significant weight gain. TCAs can increase appetite and cause cravings for carbohydrates by affecting neurotransmitters in the brain. They also have anticholinergic effects that can slow down metabolism and digestion. For individuals already struggling with the fatigue and limited mobility that often accompany chronic pain, the medication's metabolic effects can create a vicious cycle. If you're using a TCA for pain and your weight is increasing, consider discussing a lower dose or a switch to a different medication class with your doctor. Focusing on a mindful, anti-inflammatory diet can also help manage both pain and weight simultaneously.