Medications That Could Be Contributing to Your Weight Gain

37. Oral Antidiabetics

Sulfonylureas, like glipizide, and thiazolidinediones, like pioglitazone, are often used to manage type 2 diabetes by increasing insulin production or improving insulin sensitivity. However, this very action can promote fat storage and lead to gradual weight gain. In fact, a weight increase can sometimes be a sign that the medication is working, as the body is now effectively processing blood sugar. For patients, this is a frustrating paradox: successful blood sugar control at the cost of weight gain. Discussing alternative drugs like metformin or GLP-1 agonists, which have weight-neutral or even weight-loss effects, can be an important part of a holistic treatment plan.

38. Inhaled Corticosteroids

It's easy to overlook inhaled corticosteroids used for asthma and COPD. While the dose is lower and goes directly to the lungs, a small amount is still absorbed systemically, especially at high doses. Over time, this can lead to subtle metabolic changes. These medications can increase appetite and contribute to fat accumulation, particularly around the abdomen, which is a classic side effect of steroid use. This effect is often minor, but for someone already struggling with weight or a sedentary lifestyle due to their condition, it can be a frustrating and unexpected hurdle.