Medications That Could Be Contributing to Your Weight Gain

41. Mood Stabilizers Beyond Lithium

There is a category of mood stabilizers can have a significant impact on weight. A prime example is divalproex sodium (Depakote), which is used to treat bipolar disorder and migraines. It's known to cause substantial weight gain in up to 50% of patients. The drug's mechanism is complex, but it's thought to slow metabolism, increase appetite, and disrupt insulin signaling. This can be particularly challenging for patients who are already dealing with the mental and emotional strain of bipolar disorder. The key is to discuss the potential for weight gain with your doctor from the outset and explore weight-neutral alternatives like lamotrigine or topiramate if a different medication is an option.

42. Hormonal Cancer Therapies: A New Metabolic Challenge

While chemotherapy can cause weight changes, some hormonal therapies used for cancers like breast or prostate cancer can also lead to significant weight gain. Medications like tamoxifen and aromatase inhibitors (e.g., letrozole) work by blocking or reducing estrogen. This hormonal shift can slow metabolism, increase body fat, and cause fluid retention. For many patients, these effects are frustrating as they're trying to maintain health during a difficult time. To manage this, patients can work with their oncology team to prioritize a high-protein diet, focus on strength training to build muscle (which boosts metabolism), and manage fluid retention by staying well-hydrated and reducing sodium intake.