Medications That Could Be Contributing to Your Weight Gain

45. Hepatitis C Medications: The Weight of Wellness

A unique and positive example of medication-induced weight gain comes from newer Hepatitis C medications. Drugs like sofosbuvir/ledipasvir (Harvoni) are highly effective at curing the virus. The resulting weight gain is often a sign of improved health. Before treatment, many patients were malnourished and fatigued due to their illness. As their liver function improves and their appetite returns, they may finally gain weight and body fat. This is a welcome change for a body that was previously in a state of chronic illness. Managing this new, healthy weight gain can be achieved through portion control and adopting a balanced, nutrient-rich diet.

46. CFTR Modulators: A Sign of Improved Health

For individuals with Cystic Fibrosis (CF), a genetic disease that makes it difficult to gain weight, a new class of drugs called CFTR modulators (like Trikafta) has been a game-changer. These medications improve lung function and nutrient absorption, which can lead to significant and often rapid weight gain. This is a direct sign that the medication is working and the patient is becoming healthier. However, a body unaccustomed to weight gain may require support. Patients can work with a dietitian to ensure this weight is healthy and sustainable, avoiding excessive fat accumulation by focusing on a balanced diet and regular exercise.